Common Conditions Treated

Here are common diagnoses that allergists and immunologists frequently evaluate and treat.

Allergic Conditions

• Allergic rhinitis (seasonal or perennial hay fever)
• Asthma, including allergic and exercise-induced asthma
• Atopic dermatitis (eczema)
• Urticaria (hives)
  • Acute urticaria
  • Chronic spontaneous urticaria
• Angioedema, including histaminergic and bradykinin-mediated swelling
• Allergic conjunctivitis

Food & Drug Allergy

Food Allergies

• Peanut and tree nut allergies
• Milk, egg, wheat, and soy allergies
• Shellfish and fish allergies
• Food-dependent exercise-induced anaphylaxis
• Oral allergy syndrome (pollen-food allergy syndrome)

Drug Allergies

• Penicillin and beta-lactam allergies
• NSAID and aspirin reactions
• Sulfa drug allergies
• Chemotherapy and biologic medication reactions
• Vaccine reaction evaluations

Anaphylaxis

• Idiopathic anaphylaxis
• Food-induced anaphylaxis
• Venom-induced anaphylaxis
• Peri-operative anaphylaxis

Venom & Environmental Allergy

• Insect sting allergy
  • Honeybee
  • Wasp
  • Hornet
  • Yellow jacket
  • Fire ant
• Mold allergy
• Animal dander allergy
• Dust mite allergy

Eosinophilic Disorders

• Eosinophilic esophagitis (EoE)
• Eosinophilic gastrointestinal disorders
• Hypereosinophilic syndromes

Immunologic & Immune Deficiency Disorders

Primary Immunodeficiencies

• Common Variable Immune Deficiency (CVID)
• Selective IgA deficiency
• Specific antibody deficiency
• IgG subclass deficiency
• X-linked agammaglobulinemia

Recurrent Infection Evaluation

• Chronic sinus and respiratory infections
• Recurrent skin infections
• Immune system dysfunction

Non-Allergic & Mimicking Conditions

• Non-allergic rhinitis
• Chronic cough syndromes
• Vocal cord dysfunction
• Mast cell activation disorders
• Hereditary angioedema (HAE)
• Food intolerance (non-allergic reactions)

Other Common Consultation Reasons

• Adverse reactions to foods or additives
• Unexplained rashes
• Evaluation of multiple suspected allergies
• Pre-biologic or medication desensitization evaluations
• Occupational allergies

Clinical Immunology Conditions

Primary Immunodeficiency Disorders

Antibody Deficiencies

• Common Variable Immune Deficiency (CVID)
• Selective IgA deficiency
• Specific antibody deficiency
• IgG subclass deficiency
• X-linked agammaglobulinemia

Combined Immunodeficiencies

• Severe Combined Immunodeficiency (SCID)
• Leaky SCID
• Combined immunodeficiency with autoimmunity

Phagocytic Disorders

• Chronic granulomatous disease (CGD)
• Leukocyte adhesion deficiency
• Chediak-Higashi syndrome

Complement Disorders

• C1 inhibitor deficiency
• C2, C3, and C4 deficiencies
• Terminal complement deficiencies (C5–C9)

Secondary (Acquired) Immunodeficiency

• Immune dysfunction related to chronic corticosteroid use
• Chemotherapy or biologic therapy
• Hematologic malignancy
• Organ or stem cell transplant
• Hypogammaglobulinemia
• Protein-losing enteropathy or nephrotic syndrome
• Age-related immune dysfunction

Immune Dysregulation & Autoimmunity

• Autoimmune disease with immune deficiency
• CVID-associated autoimmunity
• Autoimmune cytopenias
• Evans syndrome
• Autoimmune lymphoproliferative syndrome (ALPS)
• Immune checkpoint inhibitor-related toxicity

Autoinflammatory & Periodic Fever Syndromes

• Familial Mediterranean fever (FMF)
• Cryopyrin-associated periodic syndromes (CAPS)
• TNF receptor-associated periodic syndrome (TRAPS)
• PFAPA syndrome
• Mevalonate kinase deficiency (Hyper-IgD syndrome)

Mast Cell & Histamine Disorders

• Mast Cell Activation Syndrome (MCAS)
• Systemic mastocytosis
• Idiopathic anaphylaxis
• Unexplained flushing or syncope

Hereditary Angioedema (HAE)

• Type I and II HAE (C1-INH deficiency)
• HAE with normal C1-INH
• Acquired angioedema

Immune-Related Lung & Gastrointestinal Disease

• Granulomatous-lymphocytic interstitial lung disease (GLILD)
• Bronchiectasis related to immune deficiency
• CVID-associated inflammatory bowel disease

Vaccinology & Immune Evaluation

• Poor vaccine response evaluation
• Pre-biologic immune assessment
• Vaccine safety evaluation in immunodeficient patients
• Post-vaccine immune reactions

Additional Conditions Seen in Allergy & Immunology Clinics

• Unexplained recurrent infections
• Chronic fatigue with immune abnormalities
• Suspected immune weakness
• Abnormal lymphocyte subsets or immunoglobulin levels
• Failure to thrive in children